As much as 50 percent of the female population in the United States over the age of 65 should be actively concerned about maintaining good bone health. As women age, they experience an overall increase in bone loss compared to bone formation. Concern about maintaining good bone health should begin well before menopause. Because some bone loss during menopause is inevitable, the more bone a woman has "banked" earlier in life the greater her peak bone mass will be, and hence, menopausal bone loss can have less of an adverse impact. Even women in the 18-35 year-old age group should make an effort to promote good bone health, because physical inactivity, low body weight, eating disorders, and poor nutrition during this age span can have adverse impacts on bone health later in life.
Ensuring female bone health should consist of more than just calcium supplementation. Oscap Plus provides vitamins and minerals that promote optimal bone density. The calcium in Oscap Plus is bound to citrate-malate, one of the best-absorbed forms of dietary calcium available. Calcium (citrate-malate) as low as 500 mg daily has been shown to significantly support bone health. Adequate magnesium intake promotes bone density by regulating parathyroid hormone secretion and facilitating active calcium transport to the bones. Like calcium, the magnesium in Oscap Plus is provided in the highly absorbable citrate-malate form.
Adequate calcium and vitamin D throughout life, along with a well-balanced diet/physical activity may reduce the risk of osteoporosis in later life. Oscap Plus provides vitamin D3, which facilitates absorption of calcium; boron, which assists the body's metabolism of vitamin D and estrogen; and vanadium, which promotes bone mineral density. Research indicates elevated homocysteine levels interfere with the integrity of the bone matrix; therefore, Oscap Plus contains methylcobalamin (the active form of vitamin B12), folinic acid and 5-methyl-tetrahydrofolate, (the active forms of folic acid), and pyridoxal 5'-phosphate (the active form of vitamin B6) for their function in maintaining already normal homocysteine levels. Equisetum arvense (horsetail) has been added as an excellent source of organic silica, an element found in high concentrations in healthy bones. In addition, Oscap Plus adds the isoflavone, ipriflavone, for enhanced bone support.
Extensive human studies show ipriflavone promotes bone density; in fact, over 60 human clinical trials have demonstrated ipriflavone's effectiveness in supporting bone density. Supplementation of six capsules per day of Thorne Research's Oscap Plus provides 600 mg ipriflavone, the amount used in the majority of these studies. In addition, because research indicates the benefit of both vitamins K1 and K2 in maintaining good bone health, both are included in Oscap Plus.* Vitamin K activates osteocalcin, the protein that facilitates incorporation of calcium into the bone matrix.
Take 3 capsules two times daily or as recommended by a health-care practitioner.
Three Capsules Contain:
Vitamin D (as Vitamin D3) 300 IU.
Vitamin K (200 mcg as Vitamin K1 and 200 mcg as Vitamin K2) 400 mcg.
Vitamin B6 (as Pyridoxal 5'-Phosphate) 13.5 mg.
Folate (50 mcg as Calcium Folinate and 50 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 100 mcg.
Vitamin B12 (as Methylcobalamin) 50 mcg.
Calcium (as Calcium Citrate-Malate) 300 mg.
Magnesium (as Magnesium Citrate-Malate) 150 mg.
Ipriflavone 300 mg.
Silica (from Rice Hull concentrate) 2.5 mg.
Boron (as Boron Picolinate) 1.5 mg.
Vanadium (as Vanadium Picolinate) 50 mcg.
Other Ingredients: Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
This product does not contain wheat, gluten, corn, yeast, egg, dairy products, or artificial colors, sweeteners, or flavors. This product also does not contain lactose, palmitic acid, or magnesium, calcium, or vegetable stearates.
If pregnant, consult your health-care practitioner before using this product.
As vitamin K interferes with the effect of anticoagulant drugs (like Coumadin/warfarin), the concurrent use of Oscap Plus with these agents should be avoided.
5-methyl-tetrahydrofolate (5-MTHF) and folinic acid are not recommended concurrently with methotrexate cancer therapy, as they can interfere with methotrexate's anti-neoplastic activity; however, they have not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Subclinical lymphocytopenia (low white blood cells called lymphocytes) was noted with ipriflavone administration in 13 percent of participants in one study. Values were restored after ipriflavone withdrawal.